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KMID : 1007520030120040351
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Food Science and Biotechnology
2003 Volume.12 No. 4 p.351 ~ p.357
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Preparation of Kimchi Supplemented with Immunomodulatory Components Isolated from Licorice
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Lee, Kyong-Haeng
Hwang, Jong-Hyun/Yu, Kwang-Won
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Abstract
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when we examined the immunological effects of 20 kinds of herbal hot-water extracts to prepare kimchi supplemented with immunological components, licorice (GU-0) possessed the most potent bone marrow cell proliferating activity through Peyer´s patch and had natural Killer (NK) cell-mediated tumor cytotoxicity against the cancer cell line, Yac-1 cell. GU-0 was further fractionated into MeOH-soluble (GU-1), EtOH-soluble (GU-2) and crude polysaccharide fractions (GU-3) to isolate the immunological components. Among these fractions, only GU-3 showed significantly potent immunological activities. Oxidation of GU-3 with NaIO_(４) reduced the proliferation activity of bone marrow cells and the NK cell-mediated tumor cytotoxicity of GU-3 (activity decrease of 48.7％ and 60.4％, respectively). The PH of GU-3-supplemented kimchi was slightly lower, whereas titratable acidity was a little higher than that of conventional kimchi after 4 days. Although the maximum cell numbers of the viable total bacteria and lactic acid bacteria in GU-3-supplemented kimchi were slightly lower than those of conventional kimchi, both cell numbers were similar to those of conventional kimchi after 8 days, the optimally ripening period. In addition, the sensory properties of GU-3-supplemented kimchi, including appearance, odor, taste, texture and overall acceptability, were the same as conventional kimchi. After the optimally ripened GU-3-supplemented kimchi was extracted with hot-water, the immunological activities were confirmed in vitro. GU-3-supplemented kimchi showed very potent bone marrow cell proliferating activity and NK cell-mediated tumor cytotoxicity, whereas conventional kimchi had only intermediate activities.
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